Welcome to the Leist Lab !
The Dorenkamp-Zbinden Chair at the University of Konstanz was the first of several endowed professorships now found at the Dutch University of Utrecht (B. Blaauboer), the American Johns-Hopkins University at Baltimore (T. Hartung), the Swiss University of Geneva (P. Cosson) and the Indian Mahatma Gandhi-Doerenkamp Centers in Tichullirapalli (M. Akbarsha).
These chairs were founded by the Doerenkamp-Zbinden foundation in order to promote research and teaching in the area of the 3R (Refinement, Replacement, Reduction of animal experiments) and in the field of new toxicological approaches as formulated by the National Research Council of the USA in 2007 in its vision and roadmap document on a “Toxicology for the 21st century”.
The research at the chair for in vitro toxicology and biomedicine in Konstanz focuses on mechanisms, methods and model systems related to neurotoxicity. Embryonic stem cells are used to generate cell types and models not otherwise accessible (e.g. human neuronal subpopulations), and to study neuronal development and its disturbances. In parallel human neuronal cells are used to study mechanisms of neurodegenerative diseases and of intoxications. In a third line of research, the contribution of inflammation to neuronal damage is examined in sophisticated in vitro systems, both on the level of cellular mechanisms and of pharmacological intervention.