The ubiquitin-conjugation system and its role in cell regulatory processes

The research program of our group focuses on the enzymology of ubiquitination, with a special emphasis on the role of the ubiquitin-conjugation system in human disease and the mechanisms involved in substrate recognition and polyubiquitin chain formation. As model systems, we study several ubiquitin ligases that are involved in the regulation of cell regulatory proteins including the tumor suppressor p53 ("mechanism of action", "regulatory principles"). Furthermore, we are involved in studies characterizing the oncogenic activities of the E6 protein of cancer-associated human papillomaviruses and the influence of E6 on the activity of the ubiquitin ligase E6AP.

Our research is funded by: