Research Group of
Andreas Zumbusch

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Publications 2013

D. Dan, M. Lei, B. Yao, W. Wang, M. Winterhalder, A. Zumbusch, Y. Qi, L. Xia, S. Yan, Y. Yang, P. Gao, T. Ye, W. Zhao, "DMD-based LED-illumination super-reolution and optical sectioning microscopy", Scientific reports, 3 (2013) 1116.

S. Chabot, C. Rosazza, M. Golzio, A. Zumbusch, J. Teissié, M.-P. Rols "Nucleic acids electrotransfer: from bench to bedside", Curr. Drug Metab., 14 (2013) 200-308.

Publications 2012

K. Kopp, A. Buntru, S. Pils, T. Zimmermann, R. Frank, A. Zumbusch, C. R. Hauck "GRB14 is a negative regulator of ceacam3-mediated phagocytosis of pathogenic bacteria", J. Biol. Chem., 287 (2012) 39158-39170.

R. Galli, O. Uckermann, M.J. Winterhalder, K.H. Sitoci-Ficici, K.D. Geiger, E. Koch, G. Schackert, A. Zumbusch, G. Steiner, M. Kirsch "Vibrational spectroscopy imaging and multiphoton microscopy of spinal cord injury", Anal. Chem., 84 (2012) 8707-8714.

C. Mauroy, T. Portet, M. Winterhalder, J.-M. Escoffre, E. Bellard, M.-C. Blache, J. Teissé, A. Zumbusch, M.-P. Rols "Giant lipid vesicles under electric field pulses assessed by non invasive imaging", Bioelectrochemistry, 87 (2012) 253-259.

M. Paar, C. Jüngst, N.A. Steiner, C. Magnes, F. Sinner, D. Kolb, A. Lass, R. Zimmermann, A. Zumbusch, S.D. Kohlwein, and H. Wolinski "Remodeling Of lipid droplets during lipolysis and growth in adipocytes", J. Biol. Chem., 287 (2012) 11164-11173.

R. Selm, G. Krauss, A. Leitenstorfer, A. Zumbusch "Noniterative characterization of few-cycle laser pulses using flattop gates". Opt. Expr., 20 (2012) 5955-5961.

S. Wiktorowski, G. M. Fischer, M. J. Winterhalder, E. Daltrozzo, and A. Zumbusch "Photophysics of aminophenyl substituted pyrrolopyrrole cyanines" PhysChemChemPhys, 14 (2012) 2921 - 2928.

B.M.I. Flier, M.C. Baier, J. Huber, K. Müllen, S. Mecking, A. Zumbusch, D. Wöll "Heterogeneous Diffusion in Thin Polymer-Films as observed by High-Temperature Single Molecule Fluorescence Microscopy", J. Am. Chem. Soc., 134 (2012) 480-488.

C. Rosazza, E. Phez, J.-M. Escoffre, L. Cézanne, A. Zumbusch, M.-P. Rols "Cholesterol implications in plasmid DNA electrotransfer: evidence for the involvement of endocytotic pathways", Int. J. Pharm., 423 (2012) 134-143

F. Schütze, B. Stempfle, C. Jüngst, D. Wöll, A. Zumbusch, and S. Mecking "Fluorescent conjugated block copolymer nanoparticles by controlled mixing", Chem. Comm. 48 (2012) 2104-2106.

Publications 2011

R. Selm, G. Krauss, A. Leitenstorfer, A. Zumbusch, "Simultaneous second-harmonic generation, third-harmonic generation, and four-wave mixing microscopy with single sub-8 fs laser pulses", Appl. Phys. Lett., 99 (2011) 181124.

  • highlighted in Nature Photonics
  • selected for the Virtual Journal for Biological Physics
  • selected for the Virtual Journal of Ultrafast Science

G.M. Fischer, M.K. KLein, E. Daltrozzo, A. Zumbusch "Pyrrolopyrrole Cyanines: Effect of Substituents on Optical Properties", Eur. J. Org. Chem., 19 (2011) 3421-3429.

J. Wachtveitl and A. Zumbusch "Azobenzene: an optical switch for in vivo experiments", ChemBioChem, 12 (2011) 1169–1170.

C. Jüngst, M. Winterhalder, A. Zumbusch "Fast and long term lipid droplet tracking with CARS microscopy", J. Biophot., 4, (2011) 435–441.

C. Rosazza, J.-M. Escoffre, A. Zumbusch, M.-P. Rols "The actin cytoskeleton has an active role in the electrotransfer of plasmid DNA in mammalian cells", Mol. Ther., 19 (2011) 913-921

M. Winterhalder, A. Zumbusch, M. Lippitz, M. Orrit, "Towards Far-Field Vibrational Spectroscopy of Single Molecules at Room Temperature" J. Phys. Chem. B, 115 (2011) 5425–5430.

M. Lei, M. Winterhalder, R. Selm, A. Zumbusch "Video-rate wide-field CARS microscopy with collinear non-phase-matching illumination", J. Biomed. Opt., 16 (2011) 021104

  • selected for the Virtual Journal for Biological Physics

W. Akers, C.-H. Kim, M. Berezin, K. Guo, Kevin, R. Fuhrhop, G. Lanza, G. Fischer, Georg, E. Daltrozzo, A. Zumbusch, X. Cai, L. Wang, S. Achilefu, "Noninvasive Photoacoustic and Fluorescence Sentinel Lymph Node Identification using Dye-Loaded Perfluorocarbon Nanoparticles" ACS Nano, 5 (2011) 173–182.

B.M.I. Flier, M. Baier, J. Huber, K. Müllen, S. Mecking, A. Zumbusch, D. Wöll "Single Molecule Fluorescence Microscopy Investigations on Heterogeneity of Translational Diffusion in Thin Polymer Films", PhysChemChemPhys, 13, (2011) 1770–1775.

G.M. Fischer, E. Daltrozzo, A. Zumbusch "Selective NIR chromophores: Bis-Pyrrolopyrrole Cyanines", Angew. Chem., 123 (2011) 1442-1445 and Angew.Chem. Int. Ed., 50 (2011) 1406-1409.

  • selected by SYNFACTS as SYNFACT OF THE MONTH

Nucleic acids electrotransfer: from bench to bedside

Publications 2010

M. Lei, A. Zumbusch "TIRF microscopy with W-shaped axicon mirrors", Opt. Lett., 35 (2010) 4057-4059

J. Pecher, J. Huber, M. Winterhalder, A. Zumbusch*, S. Mecking* "Tailor-made conjugated polymer nanoparticles for multicolor and multiphoton cell imaging", Biomacromolecules, 11 (2010) 2776–2780

R. Selm, M. Winterhalder, A. Zumbusch*, G. Krauß, T. Hanke, A. Sell, A. Leitenstorfer” Ultrabroadband background-free Coherent anti-Stokes Raman Scattering microscopy based on a compact Er:fiber laser system”, Opt. Lett., 35 (2010) 3282-3284

M. Lei, A. Zumbusch, "Structured light sheet fluorescence microscopy based on four beam interference", Opt. Exp., 18 (2010) 19232–19241

  • selected for the Virtual Journal for Biomedical Optics

M. Dorfschmid, K. Müllen, A. Zumbusch, D. Wöll "Translational and Rotational Diffusion during Radical Bulk Polymerization – a Comparative Investigation by Full Correlation Fluorescence Correlation Spectroscopy (fcFCS)", Macromolecules, 43 (2010) 6174–6179

G.M. Fischer, C. Jüngst, M. Isomäki-Krondahl, D. Gauss, H.M. Möller, E. Daltrozzo, A. Zumbusch "Asymmetric PPCys: Strongly fluorescing NIR labels", Chem. Comm., 46 (2010) 5289-5291

  • selected by SYNFACTS

Publications 2009

G. Krauss, T. Hanke, A. Sell, D. Träutlein, A. Leitenstorfer. R. Selm. M. Winterhalder, A. Zumbusch "A compact coherent anti-Stokes Raman scattering microscope based on a picosecond two-color Er:fiber laser system", Opt. Lett., 34 (2009) 2847-2849

  • selected by the Virtual Journal for Ultrafast Science


M.Y. Berezin, W.J. Atkers, K. Guo, G.M. Fischer, E. Daltrozzo, A. Zumbusch, S. Achilefu "Long Fluorescence Lifetime Molecular Probes Based on Near Infrared Pyrrolopyrrole Cyanine Fluorophores for in vivo imaging" Biophys. J.,97 (2009) L22-L24

G.M. Fischer, M. Isomäki-Krondahl, I. Göttker-Schnetmann, E. Daltrozzo, A. Zumbusch "Pyrrolopyrrole Cyanine (PPCy) dyes: A new class of near-infrared dyes and fluorophores" Chem. Eur. J., 15 (2009) 4857-4864

  • selected by SYNFACTS

Publications 2007

M. Müller, A. Zumbusch "Coherent Anti-Stokes Raman Scattering (CARS) microscopy" ChemPhysChem 8 (2007) 2156-2169

S. Wörmke, S. Mackowski, T. H. P. Brotosudarmo, C. Jung, A. Zumbusch, M. Ehrl, H. Scheer, E. Hofmann, R. G. Hiller, C. Bräuchle "Monitoring fluorescence of individual chromophores in peridinin-chlorophyll-protein complex using single molecule spectroscopy" Biochim. Biophys. Acta, 1767 (2007) 956-964

G.M. Fischer, A. Ehlers, A. Zumbusch, E. Daltrozzo "Near Infrared Dyes and Fluorophores Based on Diketopyrrolopyrroles" Angew. Chem. Int. Ed. 46 (2007) 3750-3753 and "NIR-Farbstoffe und NIR-Fluorophore aus Diketopyrrolopyrrolen" Angew. Chem. 119 (2007) 3824-3827

Publications 2006

A. Kiraz, M. Ehrl, Th. Hellerer, Ö. E. Mustecaplioglu, C. Bräuchle, and A. Zumbusch "Observation of Two-Photon Interference Using the Zero-Phonon-Line Emission of a Single Molecule" Jounal of Physics: Conf. Ser. 36 (2006) 67-71.

O. Burkacky, C. Brackmann, A. Zumbusch, A. Enejder "Dual-pump coherent anti-Stokes Raman scattering microscopy" Opt. Lett. 31 (2006) 3656-3658.

T.H.P. Brotosudarmo, E. Hofmann, R.G. Hiller, S. Wörmke, S. Mackowski, A. Zumbusch, C. Bräuchle, H. Scheer "Peridinin-chlorophyll-protein reconstituted with chlorophyll mixtures: Preparation, bulk, and single molecule spectroscopy" FEBS Lett. 580 (2006) 5257-5262.

G. Jung, A. Zumbusch "Improving autofluorescent proteins: Comparative studies of the effective brightness of Green Fluorescent Protein (GFP) mutants" Micr. Res. Tech. 69 (2006) 175-185.

A. Zumbusch, O. Burkacky "Chemische Selektivität ohne Anfaerben: CARS-Mikroskopie" Nachr. Chem. 54 (2006) 38

R. Bausinger, K. von Gersdorff, K. Braeckmans, M. Ogris, E. Wagner, C. Bräuchle, A. Zumbusch "The Transport of Nanosized Gene Carriers Unravelled by Live Cell Imaging" Angew. Chemie 118 (2006) 1598-1602 and Angew.Chem. Int. Ed. 45 (2006) 1568–1572.

Publications 2005

A. Scherer, C. Zhou, J. Michaelis, C. Bräuchle, A. Zumbusch, "Inter-molecular interactions of polymer molecules determined by single-molecule force spectroscopy" Macromolecules 38 (2005) 9821-9825.

A. Zumbusch, A. Volkmer "Einblick in das Unsichtbare" Physik Journal 4 (2005) 31-37.

C. Krinninger, C. Högg, H. Nöth, J. C. Galvez Ruiz, P. Mayer, O. Burkacky, A. Zumbusch, I.-P. Lorenz "New dichroic, dinuclear µ2 -(η 2 -NO)-nitrosoaniline-bridged complexes of rhenium of the type [{(CO)3ReX}2ONC6H4NR2] (X = Cl, Br, I; R = Me, Et)" Chem. Eur. J. 11 (2005)7228-7236.

A. Kiraz, M. Ehrl, Th. Hellerer, Ö. Mustecaplioglu, C. Bräuchle, A. Zumbusch "Indistinguishable Photons from a Single Molecule", Phys. Rev. Lett. 94 (2005) 223602

  • selected by the Virtual Journal for Biological Physics Research
  • selected by the Virtual Journal for Quantum Information
  • selected by the Virtual Journal for Nanoscale Science and Technology


A. Kiraz, M. Ehrl, C. Hellriegel, C. Bräuchle, A. Zumbusch "Vibronic excitation of single molecules: A new technique for studies of low temperature dynamics", ChemPhysChem 6 (2005) 919-925.

H.-J. Musiol, S. Dong, M. Kaiser, R. Bausinger, A. Zumbusch, L. Moroder "Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation Chemistry", ChemBioChem 6 (2005) 625-628.

A. Hards, C. Zhou, M. Seitz, C. Bräuchle, A. Zumbusch "Simultaneous AFM manipulation and optical imaging of single DNA strands", ChemPhysChem 6 (2005) 534-540.

J. Wiehler, G. Jung, A. Zumbusch "The photophysics of Green Fluorescent Protein: Influence of the key amino acids at positions 65,203, and 222", Biophys. J. 88 (2005) 1932-1947.

Publications 2004

A. Kiraz, M. Ehrl, C. Bräuchle, A. Zumbusch "Ultralong coherence times in the purely electronic zero-phonon line emission of single molecules", Appl. Phys. Lett. 85 (2004) 920-922.

  • selected by the Virtual Journal for Biological Physics Research
  • selected by the Virtual Journal for Quantum Information

Th. Hellerer, A.M.K. Enejder, A. Zumbusch, "Spectral focusing: High spectral resolution spectroscopy with chirped, broad-band femtosecond pulses", Appl. Phys. Lett. 85 (2004) 25-27.

  • selected by the Virtual Journal for Ultrafast Science

Th. Hellerer, A.M. K. Enejder, O. Burkacky, A. Zumbusch "Highly efficient coherent anti-Stokes Raman scattering (CARS)-microscopy of biological samples", Proc. SPIE Int. Soc. Opt. Eng. 5323 (2004) 223-229.

P. Zehetmayer, M.Kupka, H. Scheer, A. Zumbusch, "Energy transfer in monomeric Phycoerythrocyanin (PEC)" Biochim. Biophys. Acta Bioenergetics 1608 (2004) 35-44.

Publications 2003

A. Kiraz, M. Ehrl, C. Bräuchle, A. Zumbusch "Low temperature single molecule spectroscopy using vibronic excitation and dispersed fluorescence detection" J. Chem. Phys., 118 (2003) 10821-10824.

J. Wiehler, G. Jung, C. Seebacher, A. Zumbusch, B. Steipe "Mutagenic Stabilization of the Photocycle Intermediate of Green Fluorescent Protein (GFP)" ChemBioChem, 4 (2003) 1164-1171.

J.H. Bae, M. Rubini, G. Jung, G. Wiegand, M.H.J. Seifert, M.K. Azim, J.-S. Kim, A. Zumbusch, T.A. Holak, L. Moroder, R. Huber, N. Budisa "Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins" J. Mol. Biol., 328 (2003) 1071

Publication 2002

P. Zehetmayer, Th. Hellerer, A. Parbel, H. Scheer, A. Zumbusch, "Spectroscopy of single phycoerythrocyanin monomers: Dark state identification and observation of energy transfer heterogeneities " Biophys. J., 83 (2002) 407-415.

Th. Hellerer, A. Schiller, G. Jung, A. Zumbusch, "Coherent Anti-Stokes Raman Scattering (CARS) Correlation Spectroscopy" ChemPhysChem, 3 (2002) 630

G. Jung, Th. Hellerer, B. Heinz, A. Zumbusch "Two-color correlation spectroscopy" Proc. SPIE Int. Soc. Opt. Eng. 4620 (2002) 48-53.

Publications 2001

G. Jung, J. Wiehler, B. Steipe, C. Bräuchle, A. Zumbusch, "Single-Molecule Microscopy of the Green Fluorescent Protein Using Simultaneous Two-Color Excitation" ChemPhysChem, 2 (2001) 392

G. Jung, C. Bräuchle, A. Zumbusch, "Two-color fluorescence correlation spectroscopy of one chromophore: Applications to the E222Q mutant of the green fluorescent protein" J. Chem. Phys., 114 (2001) 3149

  • selected by the Virtual Journal for Biological Physics Research

Publications 2000

G. Jung, S. Mais, A. Zumbusch, C. Bräuchle, "The Role of Dark States in the Photodynamics of the Green Fluorescent Protein Examined with Two-Color Fluorescence Excitation Spectroscopy" J. Phys. Chem. A, 104 (2000) 873

A. Zumbusch, G. Jung, "Single Molecule Spectroscopy of the Green Fluorescent Protein: A Critical Assessment" Single Mol., 1 (2000) 261

Publications 1999

A. Zumbusch, G. R. Holtom, X. S. Xie, "Three-dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering" Phys. Rev. Lett. 82(1999) 4142-4145

M. Friesen, M. Junker, A. Zumbusch, H. Schnöckel "Raman-spectroscopy of oligomeric SiO species isolated in solid methane" J. Chem. Phys. 111 (1999) 7881

A. Zumbusch, H. Schnöckel "Raman and IR spectroscopy of (GeO)_n, with n=1,2,3,4, isolated in solid argon" J. Chem. Phys. 108 (1998) 8092

Publications 1995

Fleury, L., Zumbusch, A., Orrit, M., Brown, R., Bernard, J., "Spectral diffusion and individual two-level systems probed by fluorescence of single terrylene molecules in a polyethylene matrix" J. Luminesc., 56 (1993) 15

Zumbusch, A., Fleury, L., Brown, R., Bernard, J., Orrit, M., "Probing Individual Two-Level Systems in a Polymer by Correlation of Single Molecule Fluorescence" Phys. Rev. Lett., 70 (1993) 3584

Orrit, M., Bernard, J., Zumbusch, A., Personov, R. I., "Stark effect on single molecules in a polymer matrix" Chem. Phys. Lett., 196 (1992) 595

Patent

G. Holtom, X.S. Xie, A. Zumbusch, "Nonlinear vibrational microscopy" US Pat. #6,108,081 (2000)