Molecular Toxicology Group



Chair:  Prof. Alexander Bürkle, MD

Team Members



NEW!! Joint Master Thesis project with Empa, St. Gallen

Arthur Fischbach appointed 'Associated Zukunftskolleg Fellow'

DFG-scholarship awarded to Dr. Maria Moreno-Villanueva for a research stay at NASA

BIOPRO: Molecular effects of traumatic stress

BIOPRO: Innovative measurement of cellular stress

Press releases of the MARK-AGE consortium


Selected recent publications:

Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.
Rank L, Veith S, Gwosch EC, Demgenski J, Ganz M, Jongmans MC, Vogel C, Fischbach A, Buerger S, Fischer JM, Zubel T, Stier A, Renner C, Schmalz M, Beneke S, Groettrup M, Kuiper RP, Bürkle A, Ferrando-May E, Mangerich A. Nucleic Acids Res. 2016 Dec 1;44(21):10386-10405.

MARK-AGE Special Issue published in Mechanisms of Ageing and Development 

Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.
Mangerich A, Debiak M, Birtel M, Ponath V, Balszuweit F, Lex K, Martello R, Burckhardt-Boer W, Strobelt R, Siegert M, Thiermann H, Steinritz D, Schmidt A, Bürkle A.  Toxicol Lett. 2015 Sep 14.

Day and night variations in the repair of ionizing-radiation-induced DNA damage in mouse splenocytes.
Palombo P, Moreno-Villanueva M, Mangerich A DNA Repair 2015 Feb 10

RecQ helicases and PARP1 team up in maintaining genome integrity.
Veith S. and Mangerich A. Ageing Res Rev. 2014 Dec 30

Molecular consequences of psychological stress in human aging.
Moreno-Villanueva M. and Bürkle A. Exp Gerontol. 2014 Dec 3 PubMed PMID: 25481270.

Effects of Psychotherapy on DNA Strand Break Accumulation Originating from Traumatic Stress.
Morath, J., M. Moreno-Villanueva, G. Hamuni, S. Kolassa, M. Ruf-Leuschner, M. Schauer, T. Elbert, A. Bürkle and I. T. Kolassa. Psychotherapy and Psychosomatics 2014 Aug 6 83(5): 289-297.

Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function.
Fischer JM, Popp O, Gebhard D, Veith S, Fischbach A, Beneke S, Leitenstorfer A, Bergemann J, Scheffner M, Ferrando-May E, Mangerich A, Bürkle A. FEBS J. 2014 Jun 23. doi:10.1111/febs.12885. PubMed PMID: 24953096