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Publications 2015-

  1. Formal Total Synthesis of (±)-Strictamine by [2,3]-Sigmatropic Stevens Rearrangements
    R. Eckermann, M. Breunig, T. Gaich
    Chem. Eur. J. 2017, 23 (16), 3938–3949.
  2. Cyclohepta[b]indoles: A Privileged Structure Motif in Natural Products and Drug Design
    E. Stempel, T. Gaich,
    Acc. Chem. Res. 2016, 49 (11), 2390-2402



  3. Total Syntheses of Vellosimine, N-Methylvellosimine, and 10-Methoxyvellosimine and Formal Synthesis of 16-Epinormacusine B through a [5+2] Cycloaddition
    S. Krüger, T. Gaich,
    Eur. J. Org. Chem. 2016, (28), 4893-4899



  4. The Rhazinilam-Leuconoxine-Mersicarpine Triad of Monoterpenoid Indole Alkaloids
    M. Pfaffenbach, T. Gaich, in The Alkaloids: Chemistry and Biology Vol. 77,
    Chapter 4: Aspidosperma Derived Alkaloids: The Leuconolam-Leuconoxine-Mersicarpine Triad, Academic Press, accepted.
    ISBN: 9780128111246, Abstract

  5. Formal Total Synthesis of (±)-Strictamine — The [2,3]-Stevens Rearrangement for Construction of Octahydro-2H-2,8-Methanoquinolizines
    R. Eckermann, M. Breunig, T. Gaich,
    Chem. Commun. 2016, 52 (76), 11363-11365



  6. Synthesis of Indolophanes via Photochemical Macrocyclization
    M. Pfaffenbach, A. Roller, T. Gaich,
    Chem. Eur. J. 2016, 22 (25), 8444-8447



  7. The double bond configuration of Corynanthean Alkaloids, and its impact on monoterpenoid indole alkaloid biosynthesis
    R. Eckermann, T. Gaich,
    Chem. Eur. J. 2016, 22 (16), 5749-5755



  8. The Diaza[5.5.6.6]fenestrane Skeleton-Synthesis of Leuconoxine Alkaloids
    M. Pfaffenbach, T. Gaich,
    Chem. Eur. J. 2015, 22 (11), 3600-3610



  9. A Flexible Route to Indole Scaffolds – Formal Synthesis of (±)-Mersicarpine
    M. Pfaffenbach, T. Gaich,
    Eur. J. Org. Chem. 2015, 16, 3427-3429



  10. A Photoinduced Cyclization Cascade—Total Synthesis of (−)-Leuconoxine
    M. Pfaffenbach, T. Gaich,
    Chem. Eur. J. 2015, 21, 6355–6357



  11. Enantioselective, Protecting-Group-Free Total Synthesis of Sarpagine Alkaloids—A Generalized Approach
    S. Krüger, T. Gaich,
    Angew. Chem. Int. Ed. 2015, 54 (1), 315–317



    Mentioned in Synfacts:
    Synthesis of Sarpagine Alkaloids
    Synfacts 2015, 11 (1), 7

Publications 2010-2014

  1. Light-Mediated Total Synthesis of 17-Deoxyprovidencin
    N. Tölle, H. Weinstabl, T. Gaich, J.  Mulzer,
    Angew. Chem. Int. Ed. 2014, 53 (15), 3859-3862



  2. Recent applications of the divinylcyclopropane–cycloheptadiene rearrangement in organic synthesis
    S. Krüger, T. Gaich,
    Beilstein J. Org. Chem. 2014, 10, 163–193



  3. The Witkop Cyclization: A Photoinduced C—H Activation of the Indole System
    P. Gritsch, C. Leitner, M. Pfaffenbach, T. Gaich,
    Angew. Chem. Int. Ed. 2014, 53 (5), 1208–1217



  4. Enantioselective Synthesis of Cyclohepta[b]indoles: Gram-Scale Synthesis of (S)-SIRT1-Inhibitor IV
    P. Gritsch, E. Stempel, T. Gaich,
    Org. Lett. 2013, 15 (21), 5472–5475



    Mentioned in Synfacts:
    Synthesis of a SIRT1 Inhibitor
    Synfacts 2014, 10 (1), 12

  5. The Akuammiline Alkaloids: Origin and Synthesis
    R. Eckermann, T. Gaich,
    Synthesis 2013, 45, 2813–2823



  6. How to ‘Cope’ with the Prenylation of the Indole C4-Position
    D. Schwarzer, P. Gritsch, T. Gaich,
    Synlett 2013, 24, 1025–1031



  7. Application of the Rodriguez–Pattenden Photo-Ring Contraction: Total Synthesis and Configurational Reassignment of 11-Gorgiacerol and 11-Epigorgiacerol
    H. Weinstabl, T. Gaich, J. Mulzer,
    Org. Lett. 2012, 14 (11), 2834-2837



  8. Mimicking Dimethylallyltryptophan Synthase: Experimental Evidence for a Biosynthetic Cope Rearrangement Process
    D. Schwarzer, P. Gritsch, T. Gaich,
    Angew. Chem. Int. Ed. 2012, 51 (46), 11514–11516



  9. Biomimetic Synthesis of Alkaloids with a Modified Indole Nucleus
    T. Gaich, J. Mulzer, in Biomimetic Organic Synthesis, Wiley-VCH Verlag, Weinheim, 2012, 149–180
    ISBN: 9783527325801
    Abstract

  10. Enantioselective Total Syntheses of (−)-Palau’amine, (−)-Axinellamines, and (−)-Massadines
    I. B. Seiple, S. Su, I. S. Young, A. Nakamura, J. Yamaguchi, L. Jorgensen, R. A. Rodriguez, D. P. O'Malley, T. Gaich, M. Koeck, P. S. Baran,
    J. Am. Chem. Soc. 2011, 133 (37), 14710–14726

  11. From Silphinenes to Penifulvins: A Biomimetic Approach to Penifulvins B and C
    T. Gaich, J. Mulzer,
    Org. Lett. 2010, 12 (2), 272-275



  12. Aiming for the Ideal Synthesis
    T. Gaich, P. S. Baran,
    J. Org. Chem. 2010, 75 (14), 4657–4673




Publications 2005–2009

  1. Total Synthesis of (−)-Penifulvin A, an Insecticide with a Dioxafenestrane Skeleton
    T. Gaich, J. Mulzer,
    J. Am. Chem. Soc. 2009, 131 (2), 452–453



  2. Synthetic Efforts Towards the Synthesis of the Complex Diterpene Providencin
    T. Gaich, H. Weinstabl, J. Mulzer,
    Synlett 2009, 9, 1357–1366




  3. It All Began with an Error: The Nomofungin/Communesin Story
    P. Siengalewicz, T. Gaich, J. Mulzer,
    Angew. Chem. Int. Ed. 2008, 47 (43), 8170–8176



  4. Synthesis of the Cyclobutane Moiety of Providencin
    T. Gaich, V. Arion, J. Mulzer,
    Heterocycles 2007, 74 (1), 855–862



  5. Synthetic Studies towards the Total Synthesis of Providencin
    E. Schweizer, T. Gaich, L. Brecker, J. Mulzer,
    Synthesis 2007, 24, 3807–3814



  6. Metathesis reaction and olefin ring closing metathesis for organic synthesis
    T. Gaich, E. Ohler, J. Mulzer,
    Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
    , Elsevier, Amsterdam, 2007, 207–269.
    ISBN: 9780124095472
    Abstract

  7. New Solutions to the C-12,13 Stereoproblem of Epothilones B and D; Synthesis of a 12,13-Diol-Acetonide Epothilone B Analog
    T. Gaich, G.  Karig, H. J. Martin, J. Mulzer,
    Eur. J. Org. Chem. 2006, 15, 3372–3394



  8. Recent Applications of Olefin Ring-Closing Metathesis (RCM) in the Synthesis of Biologically Important Alkaloids, Terpenoids, Polyketides and Other Secondary Metabolites
    T. Gaich, J. Mulzer,
    Curr. Top. Med. Chem. 2005, 5 (15), 1473–1494

  9. Synthesis of Epothilones via a Silicon-Tethered RCM Reaction
    T. Gaich, J. Mulzer,
    Org. Lett. 2005, 7 (7), 1311–1313