Our group is focused on the total synthesis of polycyclic natural products, which exhibit a unique molecular architecture. The synthetic strategy we follow is governed by the (often postulated) biosynthesis of the respective structure. In a biosynthetic process molecular complexity very often originates from a domino reaction sequence. Establishing the chemical feasibility of such an avalanche of bond-forming events drastically raises synthetic efficiency, i.e. reduces the number of steps, and lowers the costs. Moreover Nature’s pathways to us serve as a source of inspiration for the development of new synthetic methodologies.